TargetMol

Imatinib impurities3

Product Code:
 
TAR-T67847
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67847-5mg5mg£111.00
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TAR-T67847-10mg10mg£131.00
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TAR-T67847-25mg25mg£173.00
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TAR-T67847-50mg50mg£225.00
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Quantity:
TAR-T67847-100mg100mg£301.00
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This product comes from: United States.
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Further Information

Bioactivity:
Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.
CAS:
404844-11-7
Formula:
C24H20ClN5O
Molecular Weight:
429.9
Pathway:
Tyrosine Kinase/Adaptors|Angiogenesis|Cytoskeletal Signaling
Purity:
0.9705
SMILES:
O=C(NC1=CC=C(C(=C1)NC=2N=CC=C(N2)C3=CN=CC=C3)C)C4=CC=C(C=C4)CCl
Target:
PDGFR|c-Kit|Bcr-Abl

References

Leproult E, et al. Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55.