TargetMol

LGB-321 HCl

Product Code:
 
TAR-T71227
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T71227-5mg5mg£1,492.00
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TAR-T71227-50mg50mg£2,946.00
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Quantity:
TAR-T71227-100mg100mg£4,006.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
LGB-321 is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor). LGB321 is unique relative to previously described PIM inhibitors, in that it is active in PIM2 dependent cell lines. , a kinase that has proven difficult to inhibit in the cellular context. Consistent with its activity on all three PIM kinases, LGB321 inhibits proliferation of a number of cell lines derived from diverse hematological malignancies, including MM, AML, CML and B-Cell NHL. In vivo, LGB-321 is orally available, demonstrates efficacy in tumor xenografts and is well-tolerated within the therapeutic exposure range in mice. (source: Clin Cancer Res. 2014 Apr 1;20(7):1834-45 )
CAS:
1210416-93-5
Molecular Weight:
530.3732
Purity:
0.98