TargetMol

MF-592

Product Code:
 
TAR-T71510
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T71510-5mg5mg£1,572.00
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TAR-T71510-50mg50mg£3,107.00
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TAR-T71510-100mg100mg£4,247.00
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This product comes from: United States.
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Further Information

Bioactivity:
MF-592 is a potent and selective antagonists of the EP4 receptor. MF-592 demonstrated good functional potency (hEP4 IC50 = 3 nM) and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (hWB) (IC50 = 78nM). In addition, it showed an excellent oral pharmacokinetic (PK) profile and in vivo efficacy in a rat chronic adjuvant-induced-arthritis model (ED50 = 0.1 mg/kg/day).. MF-592 has a desirable overall preclinical profile that suggests it is suitable for further development.
CAS:
1064195-48-7
Molecular Weight:
682.61
Purity:
0.98