TargetMol

G-573

Product Code:
 
TAR-T71891
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T71891-5mg5mg£850.00
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Quantity:
TAR-T71891-50mg50mg£1,661.00
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Quantity:
TAR-T71891-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
G-573 is an allosteric inhibitor of MEK that is both potent and selective. The IC(50) value for pERK inhibition in HCT116 tumours by G-573 was estimated to be 0.406 ?uM. The IC(50) values for tumour growth inhibition in HCT116 and H2122 were estimated to be 3.43 and 2.56 ?uM, respectively. ED(50) estimates in HCT116 and H2122 mouse xenograft models were estimated to be ~4.6 and 1.9 mg/kg/day, respectively.
CAS:
22868-35-5
Molecular Weight:
228.68
Purity:
0.98
SMILES:
Clc1cccc(c1)-c1nc2ccccc2[nH]1