TargetMol

C3001a

Product Code:
 
TAR-T71955
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T71955-5mg5mg£850.00
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Quantity:
TAR-T71955-50mg50mg£1,661.00
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Quantity:
TAR-T71955-100mg100mg£2,079.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
C3001a is a selective activator for TREK, against other two-pore domain K+(K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a targets TREK channels in the peripheral nervous system to reduce the excitability of nociceptive neurons. In neuropathic pain, C3001a alleviated spontaneous pain and cold hyperalgesia. In a mouse model of acute pancreatitis, C3001a alleviated mechanical allodynia and inflammation. C3001a represents a lead compound which could advance the rational design of peripherally acting analgesics targeting K2P channels without opioid-like adverse effects.
CAS:
1374325-56-0
Molecular Weight:
380.462
Purity:
0.98
SMILES:
Cc1ccc2nc(sc2c1)-c1ccc(NC(=O)C2CCC(C2)C(O)=O)cc1