TargetMol

SCFSkp2-IN-2

Product Code:
 
TAR-T72043
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T72043-5mg5mg£102.00
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TAR-T72043-1mL1 mL * 10 mM (in DMSO)£105.00
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TAR-T72043-10mg10mg£122.00
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TAR-T72043-25mg25mg£173.00
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TAR-T72043-50mg50mg£242.00
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TAR-T72043-100mg100mg£369.00
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Quantity:
TAR-T72043-500mg500mg£768.00
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This product comes from: United States.
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Further Information

Bioactivity:
SCFSkp2-IN-2 is a Skp2 inhibitor with a K D of 28.77 uM. AAA-237 induces apoptosis of NSCLC cells and shows antitumor activities .
CAS:
1375060-02-8
Molecular Weight:
312.37
Pathway:
Ubiquitination|Apoptosis
Purity:
0.9928
SMILES:
N(CC)(CC)C1=CC(O)=C(/C=N/NC(=O)C=2C=CC=NC2)C=C1
Target:
Apoptosis|E1/E2/E3 Enzyme

References

Melnyk P, et al. Design, synthesis and in vitro antimalarial activity of an acylhydrazone library. Bioorg Med Chem Lett. 2006;16(1):31-35. Liu J, et al. Anti-tumor effects of Skp2 inhibitor AAA-237 on NSCLC by arresting cell cycle at G0/G1 phase and inducing senescence. Pharmacol Res. 2022;181:106259.