TargetMol

JB170

Product Code:
 
TAR-T74174
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T74174-50mg50mgEnquire
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TAR-T74174-5mg5mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
JB170 is a potent and highly specific PROTAC -mediated AURORA-A ( Aurora Kinase ) degrader ( DC 50 =28 nM) by linking Alisertib, to the Cereblon -binding molecule Thalidomide. JB170 preferentially binds AURORA-A ( EC 50 =193 nM) over AURORA-B (EC 50 =1.4 uM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase [1] .
CAS:
2705844-82-0
Molecular Weight:
963.36
Purity:
0.98
SMILES:
O=C(NCCOCCOCCNC(=O)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(C=C4OC)NC=5N=CC6=C(N5)C=7C=CC(Cl)=CC7C(=NC6)C=8C(F)=CC=CC8OC