TargetMol

YF135

Product Code:
 
TAR-T74336
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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CodeSizePrice
TAR-T74336-50mg50mgEnquire
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TAR-T74336-5mg5mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
YF135 is an efficient and reversible-covalent KRAS G12C PROTAC . YF135 is designed and synthesized by tethering KRAS G12C inhibitor 48 (compound 6d) as the ligand, and basing on the scaffold of MRTX849 linkage VHL ligand. YF135 significantly induces the degradation of KRAS G12C in a reversible manner and decreases phospho-ERK level through the E3 ligase VHL mediated proteasome pathway [1] .
CAS:
2913177-53-2
Molecular Weight:
1179.86
Purity:
0.98