TargetMol

PROTAC EGFR degrader 4

Product Code:
 
TAR-T74515
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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TAR-T74515-50mg50mgEnquire
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Further Information

Bioactivity:
PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR .PROTAC EGFR degrader 4 induces EGFR del19 and EGFR L858R/T790M degradation with DC 50 s of 0.51 and 126 nM, respectively. PROTAC EGFR degrader 4 significantly inhibits growth of HCC827 and H1975 cell lines with IC 50 s of 0.83 and 203.1 nM, respectively. Induced EGFR degradation is related to autophagy [1] .
CAS:
2882845-50-1
Molecular Weight:
995.29
Purity:
0.98