TargetMol

SAH-SOS1A TFA

Product Code:
 
TAR-T76059
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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CodeSizePrice
TAR-T76059-50mg50mgEnquire
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TAR-T76059-5mg5mgEnquire
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity ( EC 50 =106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS [1] .
Molecular Weight:
2301.55
Purity:
0.98