TargetMol

AZ-23

Product Code:
 
TAR-T14363
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T14363-1mL1 mL * 10 mM (in DMSO)£188.00
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TAR-T14363-10mg10mg£244.00
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TAR-T14363-25mg25mg£444.00
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TAR-T14363-50mg50mg£711.00
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Further Information

Bioactivity:
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.
CAS:
915720-21-7
Formula:
C17H19ClFN7O
Molecular Weight:
391.83
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
CC(C)Oc1n[nH]c(Nc(nc(N[C@@H](C)c(cc2)ncc2F)nc2)c2Cl)c1
Target:
Trk receptor

References

Thress K, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol Cancer Ther. 2009 Jul; 8(7):1818-27.