TargetMol

Lometrexol disodium

Product Code:
 
TAR-T63240
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T63240-10mg10mg£994.00
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Quantity:
TAR-T63240-25mg25mg£1,661.00
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Quantity:
TAR-T63240-50mg50mg£2,472.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Lometrexol (DDATHF) disodium is a potent inhibitor of human serine hydroxymethyltransferase 1/2 (hSHMT1/2) and antifolate, which reduces the activity of glycinamide ribonucleotide formyltransferase (GARFT) without causing detectable levels of DNA strand breaks. Lometrexol disodium exhibits anticancer effects by inhibiting the de novo synthesis of purines, causing abnormal cell proliferation, apoptosis and cell cycle arrest.
CAS:
120408-07-3
Molecular Weight:
487.424
Purity:
0.98
SMILES:
[Na+].[Na+].Nc1nc2NC[C@H](CCc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)Cc2c(=O)[nH]1