TargetMol

IRAK4-IN-6

Product Code:
 
TAR-T11674
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T11674-25mg25mg£1,267.00
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Quantity:
TAR-T11674-50mg50mg£2,062.00
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This product comes from: United States.
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Further Information

Bioactivity:
IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC 50 of 4 nM. IRAK4-IN-6 targetes MyD88 L265P mutant diffuse large B cell lymphoma [1].
CAS:
2454244-02-9
Formula:
C25H32N10O2
Molecular Weight:
504.59
Purity:
0.98
SMILES:
O=C(N1CCN([C@@H]2CC[C@@H](NC3=C4C(C=CC(CC#N)=N4)=NC(NC5=CN(C)N=C5)=N3)CC2)CC1)OC

References

Degorce SL, et al. Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors TargetingMyD88L265P Mutant Diffuse Large B Cell Lymphoma. J Med Chem. 2019 Nov 1.