TargetMol

NV03

Product Code:
 
TAR-T12271
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T12271-25mg25mg£1,163.00
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TAR-T12271-50mg50mg£1,797.00
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TAR-T12271-100mg100mg£2,866.00
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Further Information

Bioactivity:
NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a K d of 2.4 uM. NV03 is a possible application as anticancer therapeutics [1].
CAS:
2448341-58-8
Formula:
C19H27N5O2S
Molecular Weight:
389.51
Purity:
0.98
SMILES:
O=C(CN1N=C(N2C(C1=O)=C(C3=C2C=CS3)C)C)NCCCN(CC)CC

References

Senisterra G, et al. Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. SLAS Discov. 2018 Oct;23(9):930-940.