TargetMol

MGV354

Product Code:
 
TAR-T12888
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1

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CodeSizePrice
TAR-T12888-25mg25mg£1,448.00
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TAR-T12888-50mg50mg£2,388.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2].
CAS:
T12888
Formula:
C35H37N5O3
Molecular Weight:
575.7
Purity:
0.98
SMILES:
O=C(C1=C(C)N(C2=NC(C3=CC=CC4=C3[C@@H](NC5=CC=C(C6CCN(C(C7CC7)=O)CC6)C=C5C)CC4)=CC=C2)N=C1)O

References

Ehara T, et al. The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma. J Med Chem. 2018 Mar 22;61(6):2552-2570. Stacy R,?et al. A Randomized, Controlled Phase I/II Study to Evaluate the Safety and Efficacy of?MGV354?for Ocular Hypertension or Glaucoma.Am J Ophthalmol.?2018 Aug;192:113-123. Prasanna G,?et al. A Novel Selective Soluble Guanylate Cyclase Activator,?MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing.Invest Ophthalmol Vis Sci.?2018 Apr 1;59(5):1704-1716.