TargetMol

MAK683-CH2CH2COOH

Product Code:
 
TAR-T13765
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T13765-25mg25mg£1,289.00
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Quantity:
TAR-T13765-50mg50mg£1,989.00
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Quantity:
TAR-T13765-100mg100mg£3,111.00
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This product comes from: United States.
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Further Information

Bioactivity:
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design EED-Targeted PROTAC which are EED degrader-1 and PROTAC EED degrader-2 [1].
CAS:
2639882-68-9
Formula:
C23H21FN6O3
Molecular Weight:
448.45
Purity:
0.98
SMILES:
FC1=CC=C2C(CCO2)=C1CNC3=NC=C(C4=C(C)N=C(CCC(O)=O)C=C4)C5=NN=CN35

References

Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.