TargetMol

DREADD agonist 21 dihydrochloride

Product Code:
 
TAR-T11095
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
DREADD agonist 21 dihydrochloride is a potent human muscarinic acetylcholine M3 receptors ( hM3Dq ) agonist with EC 50 of 1.7 nM [1].
CAS:
2250025-92-2
Formula:
C17H20Cl2N4
Molecular Weight:
351.27
Purity:
0.98
SMILES:
[H]Cl.[H]Cl.C1(N2CCNCC2)=NC3=C(NC4=C1C=CC=C4)C=CC=C3

References

Chen X, et al. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem Neurosci. 2015 Mar 18;6(3):476-84. Thompson KJ, et al. DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo. ACS Pharmacol Transl Sci. 2018 Sep 14;1(1):61-72.