TargetMol

SEN177

Product Code:
 
TAR-T61063
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T61063-100mg100mgEnquire
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Further Information

Bioactivity:
SEN177 shows the potential in the research of Huntington?s disease that is a potent inhibitor of glutaminyl cyclase (QPCT) with an IC 50 of 0.013uM for glutaminyl-peptide cyclotransferase-like (QPCTL). The Ki value of SEN177 for human glutaminyl cyclase (hQC) is 20 nM. SEN177 significantly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates [1].
CAS:
2117405-13-5
Molecular Weight:
338.39
Purity:
0.98
SMILES:
FC=1N=CC(=CC1)C2=CC=CN=C2N3CCC(C4=NN=CN4C)CC3