TargetMol

3-O-Methyltolcapone

Product Code:
 
TAR-T10119
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of Parkinson's disease.
CAS:
134612-80-9
Formula:
C15H13NO5
Molecular Weight:
287.27
Pathway:
Metabolism
Purity:
0.98
SMILES:
O=C(C1=CC=C(C=C1)C)C2=CC(OC)=C(O)C(=C2)N(=O)=O
Target:
Transferase

References

Ceravolo R, et al. 18F-dopa PET evidence that tolcapone acts as a central COMT inhibitor in Parkinson's disease. Synapse. 2002 Mar 1;43(3):201-7. Jorga K, et al. Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyltransferase. Br J Clin Pharmacol. 1999 Oct;48(4):513-20.