TargetMol

Apremilast-d5

Product Code:
 
TAR-T10350
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α release by lipopolysaccharide (IC50: 104 nM).
CAS:
1258597-47-5
Formula:
C22H24N2O7S
Molecular Weight:
465.53
Pathway:
Metabolism|Apoptosis
Purity:
0.98
SMILES:
[C@H](CS(C)(=O)=O)(N1C(=O)C=2C(C1=O)=CC=CC2NC(C)=O)C3=CC(OC(C([2H])([2H])[2H])([2H])[2H])=C(OC)C=C3
Target:
PDE|TNF

References

Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249.