TargetMol

Desfluoro-ezetimibe

Product Code:
 
TAR-T11003
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
Desfluoro-ezetimibe is the defluorinated impurity of ezetimibe. Ezetimibe is an effective, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor and an effective Nrf2 activator.
CAS:
302781-98-2
Formula:
C24H22FNO3
Molecular Weight:
391.43
Purity:
0.98
SMILES:
C(C[C@H](O)C1=CC=C(F)C=C1)[C@@H]2[C@](N(C2=O)C3=CC=CC=C3)(C4=CC=C(O)C=C4)[H]

References

Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. Bellur Atici E, et al. Identification, synthesis and characterization of process related desfluoro impurity of ezetimibe and HPLC method validations. J Pharm Anal. 2015 Dec;5(6):356-370.