TargetMol

Ezetimibe ketone

Product Code:
 
TAR-T11251
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Ezetimibe, a compound known as a Niemann-Pick C1-like1 (NPC1L1) inhibitor and a potent Nrf2 activator, effectively inhibits cholesterol absorption. Additionally, Ezetimibe ketone (EZM-K) represents a phase-I metabolite of Ezetimibe.
CAS:
191330-56-0
Formula:
C24H19F2NO3
Molecular Weight:
407.41
Pathway:
Membrane transporter/Ion channel|Immunology/Inflammation
Purity:
0.98
SMILES:
C(CC(=O)C1=CC=C(F)C=C1)[C@@H]2[C@](N(C2=O)C3=CC=C(F)C=C3)(C4=CC=C(O)C=C4)[H]
Target:
Nrf2|NPC1L1

References

Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. Synthetic Communications. 2016, 46:20, 1687-1693. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.