TargetMol

Indomethacin-D4

Product Code:
 
TAR-T11655
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.
CAS:
87377-08-0
Formula:
C19H16ClNO4
Molecular Weight:
361.81
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=C(C(=C(Cl)C(=C3[2H])[2H])[2H])[2H]
Target:
CDK

References

Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.