TargetMol

Isofistularin-3

Product Code:
 
TAR-T11682
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin.Isofistularin-3 is a direct, DNA-competitive DNMT1 inhibitor, with an IC50 of 13.5 uM.
CAS:
T11682
Formula:
C31H30Br6N4O11
Molecular Weight:
1114.01
Purity:
0.98
SMILES:
COC1=C(Br)[C@H](O)[C@@]2(ON=C(C(NC[C@H](O)COC3=C(Br)C=C([C@H](O)CNC(C4=NO[C@]5(C4)C=C(Br)C(OC)=C(Br)[C@H]5O)=O)C=C3Br)=O)C2)C=C1Br

References

Florean C, et al. Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells. Oncotarget. 2016 Apr 26;7(17):24027-49.