TargetMol

Jasplakinolide

Product Code:
 
TAR-T11712
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin.
CAS:
102396-24-7
Formula:
C36H45BrN4O6
Molecular Weight:
709.67
Pathway:
Microbiology/Virology|Cytoskeletal Signaling
Purity:
0.98
SMILES:
[H][C@@]1(CC(=O)O[C@@H](C)C[C@@H](C)C=C(C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N1)c1ccc(O)cc1
Target:
Antifungal|Microtubule Associated

References

Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27;269(21):14869-71. Holzinger A, et al. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol. 2009;586:71-87.