TargetMol

PROTAC FLT-3 degrader 1

Product Code:
 
TAR-T12555
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.
CAS:
2230826-81-8
Formula:
C52H61N9O9S2
Molecular Weight:
1020.23
Purity:
0.98
SMILES:
O(CCOCCOCCC(N[C@H](C(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)C(C)(C)C)=O)C=4C=C5C(N6C(S5)=NC(=C6)C7=CC=C(NC(NC=8C=C(C(C)(C)C)ON8)=O)C=C7)=CC4

References

Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.