TargetMol

Siomycin A

Product Code:
 
TAR-T12917
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T12917-100mg100mgEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T12917-500mg500mgEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
Siomycin A is a thiopeptide antibiotic and is a selective inhibitor of Forkhead box M1(FOXM1) without affecting other members of the Forkhead box family, has anti-tumor and promotes apoptosis.
CAS:
12656-09-6
Formula:
C71H81N19O18S5
Molecular Weight:
1648.84
Purity:
0.98
SMILES:
[H][C@]12CSC(=N1)C(NC(=O)C(NC(=O)c1csc(n1)[C@@]13CCC(=N[C@]1([H])c1csc(n1)[C@@]([H])(NC(=O)c1csc(n1)[C@@]([H])(NC2=O)[C@](C)(O)[C@@H](C)O)[C@@H](C)OC(=O)c1cc([C@H](C)O)c2C=C[C@@H](N[C@@H](C(C)C)C(=O)NC(=C)C(=O)NC(=C)C(=O)N[C@@H](C)C(=O)N3)[C@@]([H])(O)c2n1)c1nc(cs1)C(=O)NC(=C)C(=O)NC(=C)C(N)=O)[C@@H](C)O)=CC |c:4,24,70|

References

Wang B, et al. Effects and mechanism of siomycin A on the growth and apoptosis of MiaPaCa-2 cancer cells. Oncol Lett. 2019 Sep;18(3):2869-2876. Kim H, et al. Forkhead box M1 (FOXM1) transcription factor is a key oncogenic driver of aggressive human meningioma progression. Neuropathol Appl Neurobiol. 2019 Jun 9.