TargetMol

Tolcapone D7

Product Code:
 
TAR-T13181
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T13181-100mg100mgEnquire
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TAR-T13181-500mg500mgEnquire
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Further Information

Bioactivity:
Tolcapone D7 is a deuterium-labeled Tolcapone. Tolcapone is a selective and orally active inhibitor of COMT.
CAS:
T13181
Formula:
C14H4D7NO5
Molecular Weight:
280.28
Pathway:
Metabolism
Purity:
0.98
SMILES:
O=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=C([2H])C([2H])=C(C([2H])([2H])[2H])C([2H])=C2[2H]
Target:
Transferase

References

Paterson NE, et al. Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone. Neurosci Res. 2011 Jan;69(1):41-50. Di Giovanni S, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010 May 14;285(20):14941-54.