TargetMol

MS432

Product Code:
 
TAR-T13782
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T13782-100mg100mgEnquire
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TAR-T13782-500mg500mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
CAS:
T13782
Formula:
C50H65F3IN7O6S
Molecular Weight:
1076.06
Pathway:
MAPK
Purity:
0.98
SMILES:
O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCCCCCCNCCCONC(C4=CC=C(C(F)=C4NC5=CC=C(C=C5F)I)F)=O)=O)C(C)(C)C)=O
Target:
MEK

References

Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019 Dec 12;62(23):10897-10911.