TargetMol

PROTAC BRD4 Degrader-1

Product Code:
 
TAR-T13833
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
CAS:
2133360-00-4
Formula:
C40H37N9O8
Molecular Weight:
771.78
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
O=C1C=2C=CC=C(NC(=O)COCCN3N=NC(=C3)CN4C(=O)N(C5=CC=C(C=C5C4C=6C=CC=CC6)C=7C(=NOC7C)C)C)C2C(=O)N1C8C(=O)NC(=O)CC8
Target:
Epigenetic Reader Domain

References

Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.Bioorg Med Chem. 2020 Jan 1;28(1):115228.