TargetMol

Boc-NH-PEG4-CH2CH2COOH

Product Code:
 
TAR-T14006
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker employed in the synthesis of PROTAC[1]. Additionally, it is utilized as a cleavable ADC linker for antibody-drug conjugates (ADC)[2].
CAS:
756525-91-4
Formula:
C16H31NO8
Molecular Weight:
365.42
Purity:
0.98
SMILES:
O=C(OC(C)(C)C)NCCOCCOCCOCCOCCC(=O)O

References

Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1. Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2018114798A1.