TargetMol

Bis-PEG2-PFP ester

Product Code:
 
TAR-T14633
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Bis-PEG2-PFP ester is a non-cleavable 2-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs) [1]. Additionally, Bis-PEG2-PFP ester serves as a PEG-based linker for the synthesis of proteolysis targeting chimeras (PROTACs) [2].
CAS:
1314378-18-1
Formula:
C20H12F10O6
Molecular Weight:
538.29
Purity:
0.98
SMILES:
O=C(OC=1C(F)=C(F)C(F)=C(F)C1F)CCOCCOCCC(=O)OC=2C(F)=C(F)C(F)=C(F)C2F

References

An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Matthew David DOROSKI, et al. Cytotoxic peptides and antibody drug conjugates thereof. WO2013072813A2.