TargetMol

Desmethyl cariprazine

Product Code:
 
TAR-T15100
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).
CAS:
839712-15-1
Formula:
C20H30Cl2N4O
Molecular Weight:
413.38
Pathway:
GPCR/G Protein|Neuroscience
Purity:
0.98
SMILES:
ClC1=C(C=CC=C1Cl)N2CCN(CC[C@H]3CC[C@H](NC(NC)=O)CC3)CC2
Target:
5-HT Receptor|Dopamine Receptor

References

Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8. Campbell RH, et al. Review of cariprazine in management of psychiatric illness. Ment Health Clin. 2018 Mar 23;7(5):221-229.