TargetMol

Tasidotin hydrochloride

Product Code:
 
TAR-T16997
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15. Tasidotin hydrochloride is an inhibitor of microtubule assembly and microtubule dynamics.
CAS:
623174-20-9
Formula:
C32H59ClN6O5
Molecular Weight:
643.3
Pathway:
Cytoskeletal Signaling
Purity:
0.98
SMILES:
C([C@@H](N(C([C@@H](NC([C@H]([C@@H](C)C)N(C)C)=O)C(C)C)=O)C)[C@H](C)C)(=O)N1[C@H](C(=O)N2[C@H](C(NC(C)(C)C)=O)CCC2)CCC1.Cl
Target:
Microtubule Associated

References

Garg V, et al. Preclinical analysis of Tasidotin HCl in Ewing's sarcoma, rhabdomyosarcoma, synovial sarcoma, and osteosarcoma. Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5446-54. Bai R, et al. Intracellular activation and deactivation of Tasidotin, an analog of dolastatin 15: correlation with cytotoxicity. Mol Pharmacol. 2009 Jan;75(1):218-26.