TargetMol

BI-3663

Product Code:
 
TAR-T17543
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T17543-100mg100mgEnquire
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TAR-T17543-500mg500mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer activity[1].
CAS:
2341740-84-7
Molecular Weight:
917.84
Purity:
0.98
SMILES:
O=C(NCCOCCOCCOCCC(=O)NC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(NC5=NC=C(C(=N5)OC6=CC=CC7=C6C(=O)CC7)C(F)(F)F)C(OC)=C4

References

Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.