TargetMol

CL2 Linker

Product Code:
 
TAR-T17730
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T17730-100mg100mgEnquire
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TAR-T17730-500mg500mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].
CAS:
2270986-66-6
Molecular Weight:
1426.61
Purity:
0.98
SMILES:
[C@H](CC1=CC=CC=C1)(C(N[C@H](C(NC2=CC=C(COC(N(CCN(C(OCC(CO)=O)=O)C)C)=O)C=C2)=O)CCCCNC(OC(C)(C)C)=O)=O)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN3C=C(CNC(CCCCCN4C(=O)C=CC4=O)=O)N=N3)=O

References

Moon SJ, et al. Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy. J Med Chem. 2008 Nov 13;51(21):6916-26. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.