TargetMol

ATRA-hydroxyimino

Product Code:
 
TAR-T17733
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
ATRA-hydroxyimino, also known as CRABP-II ligand 1, is a chemical compound derived from Retinoic acid (ATRA). This compound binds to the cIAP1 ligand, specifically Bestatin, through a linker, resulting in the formation of a complex called SNIPER. The purpose of this complex is to degrade CRABP-II within IMR-32 cells[1].
CAS:
135325-47-2
Formula:
C20H27NO3
Molecular Weight:
329.43
Purity:
0.98
SMILES:
C(=C/C(=C/C=C/C(=C/C(O)=O)/C)/C)\C1=C(C)C(=N\O)\CCC1(C)C

References

Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.