TargetMol

DBCO-PEG4-VC-PAB-DMEA-PNU-159682

Product Code:
 
TAR-T17802
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a drug-linker conjugate for ADC, consists the ADC linker DBCO-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682[1].
CAS:
2259318-56-2
Molecular Weight:
1695.81
Purity:
0.98
SMILES:
O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4OC)C[C@](C(COC(N(CCN(C(OCC5=CC=C(NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCC(NCCC(=O)N6C=7C(C#CC=8C(C6)=CC=CC8)=CC=CC7)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C5)=O)C)C)=O)=O)(O)C1)[C@H]9C[C@@]%10(N%11[C@](O[C@@]%10([C@H](C)O9)[H])([C@@H](OC)OCC%11)[H])[H]

References

John Flygare, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods. WO2016040825A1