TargetMol

E3 ligase Ligand 10

Product Code:
 
TAR-T17868
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T17868-100mg100mgEnquire
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TAR-T17868-500mg500mgEnquire
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Further Information

Bioactivity:
E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1].
CAS:
1073560-68-5
Molecular Weight:
784.94
Purity:
0.98
SMILES:
C(OC(N([C@H](C(N[C@H](C(=O)N1[C@H](C(N[C@@H](C(C2=CC=CC=C2)C3=CC=CC=C3)C(O)=O)=O)CCC1)C4CCCCC4)=O)C)C)=O)C5C=6C(C=7C5=CC=CC7)=CC=CC6

References

Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.