TargetMol

EED226-COOH

Product Code:
 
TAR-T17931
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T17931-100mg100mgEnquire
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TAR-T17931-500mg500mgEnquire
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Further Information

Bioactivity:
EED226-COOH is an EED226-derived ligand for target protein EED ligand for PROTAC, binds to a ligand for VHL via linker to form UNC6852 to degrade PRC2[1].
CAS:
T17931
Formula:
C17H13N5O3
Molecular Weight:
335.32
Purity:
0.98
SMILES:
OC(C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4)=O

References

Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.