TargetMol

MC-Sq-Cit-PAB-Gefitinib

Product Code:
 
TAR-T18316
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T18316-100mg100mgEnquire
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TAR-T18316-500mg500mgEnquire
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Further Information

Bioactivity:
MC-Sq-Cit-PAB-Gefitinib is a drug-linker conjugate for ADC with potent antitumor activity by using Gefitinib (an EGFR tyrosine kinase inhibitor), linked via the ADC linker MC-Sq-Cit-PAB.
CAS:
1941168-63-3
Molecular Weight:
1000.53
Purity:
0.98
SMILES:
N(C=1C2=C([N+](CC3=CC=C(NC([C@@H](NC(=O)C4(C(NCCCCCN5C(=O)C=CC5=O)=O)CCC4)CCCNC(N)=O)=O)C=C3)=CN1)C=C(OC)C(OCCCN6CCOCC6)=C2)C7=CC(Cl)=C(F)C=C7

References

FLYGARE, John A, et al. Quaternary amine compounds and antibody-drug conjugates thereof. WO2016090050A1. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.