TargetMol

MC-Val-Cit-PAB-carfilzomib iodide

Product Code:
 
TAR-T18320
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
MC-Val-Cit-PAB-carfilzomib is a drug-linker conjugate for ADC with potent antitumor activity by using carfilzomib (an irreversible proteasome inhibitor), linked via the ADC linker MC-Val-Cit-PAB.
CAS:
2055896-83-6
Molecular Weight:
1275.56
Purity:
0.98
SMILES:
C([N+]1(CC(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(=O)[C@@]3(C)CO3)CC(C)C)=O)=O)CC(C)C)=O)CCC4=CC=CC=C4)=O)CCOCC1)C5=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN6C(=O)C=CC6=O)=O)[C@H](C)C)=O)CCCNC(N)=O)=O)C=C5

References

Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.