TargetMol

MC-Val-Cit-PAB-duocarmycin chloride

Product Code:
 
TAR-T18324
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T18324-500mg500mgEnquire
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Further Information

Bioactivity:
MC-Val-Cit-PAB-duocarmycin is a drug-linker conjugate for ADC with potent antitumor activity by using duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.
CAS:
2055896-98-3
Molecular Weight:
1019.6
Purity:
0.98
SMILES:
C(Cl)[C@H]1C2=C(N(C(=O)C3=CC=4C(N3)=CC=C(OCC[N+](CC5=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN6C(=O)C=CC6=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C5)(C)C)C4)C1)C=C(O)C=7C2=CC=CC7

References

Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.