TargetMol

MC-VC(S)-PABQ-Tubulysin M

Product Code:
 
TAR-T18329
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
MC-Val-Cit-PAB-tubulysin5a is a drug-linker conjugate for ADC with potent antitumor activity by using tubulysin5a (a tubulin inhibitor), linked via the ADC linker MC-Val-Cit-PAB.
CAS:
2055896-86-9
Molecular Weight:
1283.6
Purity:
0.98
SMILES:
C(N[C@H](C(N([C@H](C[C@@H](OC(C)=O)C1=NC(C(N[C@@H](CC2=CC=CC=C2)C[C@@H](C(O)=O)C)=O)=CS1)C(C)C)C)=O)[C@H](CC)C)(=O)[C@@H]3[N+](CC4=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN5C(=O)C=CC5=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C4)(C)CCCC3

References

Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.