TargetMol

Nitro-PDS-Tubulysin M

Product Code:
 
TAR-T18504
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Nitro-PDS-Tubulysin M is a drug-linker conjugate for ADC with potent antitumor activity by using Tubulysin M (a tubulin polymerization inhibitor), linked via the ADC linker Nitro-PDS.
CAS:
1941168-69-9
Molecular Weight:
1106.4
Purity:
0.98
SMILES:
C([N+]1(C)[C@@H](C(N[C@H](C(N([C@H](C[C@@H](OC(C)=O)C2=NC(C(N[C@@H](CC3=CC=CC=C3)C[C@@H](C(O)=O)C)=O)=CS2)C(C)C)C)=O)[C@H](CC)C)=O)CCCC1)C4=CC=C(NC(OC[C@H](SSC=5C=CC(N(=O)=O)=NC5)C)=O)C=C4

References

FLYGARE, John A, et al. Quaternary amine compounds and antibody-drug conjugates thereof. WO2016090050A1. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.