TargetMol

PC Mal-NHS carbonate ester

Product Code:
 
TAR-T18522
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T18522-100mg100mgEnquire
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TAR-T18522-500mg500mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
PC Mal-NHS carbonate ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. This chemical compound plays a crucial role in facilitating the conjugation of drugs to antibodies, enabling targeted delivery and enhanced efficacy of therapeutic agents. Its unique carbonate ester structure allows for efficient cleavage in the targeted environment, ensuring the controlled release of the drug payload. Its application in ADC synthesis highlights its importance in the development of innovative and targeted cancer therapies.
CAS:
1408057-91-9
Molecular Weight:
562.48
Purity:
0.98
SMILES:
O=C(ON1C(=O)CCC1=O)OC(C2=CC(OC)=C(OCCCC(=O)NCCN3C(=O)C=CC3=O)C=C2N(=O)=O)C

References

Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.