TargetMol

Phthalimide-PEG4-MPDM-OH

Product Code:
 
TAR-T18543
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T18543-100mg100mgEnquire
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TAR-T18543-500mg500mgEnquire
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Further Information

Bioactivity:
Phthalimide-PEG4-MPDM-OH, a PROTAC linker with a PEGs composition, has applications in the synthesis of various PROTACs. These PROTACs consist of a linker connecting two distinct ligands: one binds to an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively induce the degradation of target proteins [1].
CAS:
T18543
Molecular Weight:
436.5
Purity:
0.98
SMILES:
O=C(N1CCOCCOCCOCCO[C@@H]2C[C@@H](CO)N(C)C2)C3=C(C=CC=C3)C1=O

References

CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.