TargetMol

Pomalidomide-amido-PEG3-C2-NH2

Product Code:
 
TAR-T18553
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1]
CAS:
2328070-52-4
Molecular Weight:
476.48
Purity:
0.98
SMILES:
O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NC(=O)CCOCCOCCOCCN)C3C2=O)CC1

References

Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.