TargetMol

Pomalidomide-PEG6-butyl iodide

Product Code:
 
TAR-T18557
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Pomalidomide-PEG6-butyl iodide is a chemically synthesized conjugate compound that functions as an E3 ligase ligand-linker conjugate. It combines the cereblon ligand derived from Pomalidomide with a 6-unit PEG linker, which is commonly utilized in PROTAC technology[1].
CAS:
1835705-74-2
Molecular Weight:
761.6
Purity:
0.98
SMILES:
O=C(NC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)COCCOCCOCCOCCOCCOCCCCCCI

References

Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.