TargetMol

PROTAC ER Degrader-2

Product Code:
 
TAR-T18606
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T18606-100mg100mgEnquire
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TAR-T18606-500mg500mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
PROTAC ER Degrader-2 serves as a synthesis intermediate for the production of PAC, a compound that incorporates the ADCs linker and PROTACs, which are subsequently conjugated to an antibody. PAC, derived from patent WO2017201449A1 compound LP2, exhibits a greater capability to degrade estrogen receptor-alpha (ERα) compared to PROTAC (without the presence of an antibody)[1].
CAS:
T18606
Molecular Weight:
1581.85
Purity:
0.98
SMILES:
CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C(COCCOCCNC(C3=CC=C(C(N4[C@@H](C)[C@H](NC([C@H](C)N(C(OC(C)(C)C)=O)C)=O)C(N(CC5=C(OC)C=CC6=C5C=CC=C6)C7=C4C=C(C#N)C=C7)=O)=O)C=C3)=O)=O)C=C2)\C8=CC=C(OCC9=CC=C(NC([C@@H](NC([C@H](C(C)C)N)=O)CCCNC(N)=O)=O)C=C9)C=C8

References

Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.